MKC9989|1338934-20-5|-陌孚医药/Medlife

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MKC9989

目录号: PL02642 纯度: ≥98%

CAS No. :1338934-20-5

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中文名称	MKC9989
英文名称	MKC9989
英文别名	MKC9989;7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxochromene-8-carbaldehyde;BDBM160417;US9040714, 127;7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2h-chromene-8-carbaldehyde
Cas No.	1338934-20-5
分子式	C₁₇H₂₀O₇
分子量	336.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	MKC9989 是一种 HAA 抑制剂，且能抑制 IRE1α 其 IC₅₀ 值在 0.23 μM 至 44 μM 的范围之间。
生物活性	MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC 50 of 0.23 to 44 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 0.23 to 44 μM (IRE1α)
体外研究(In Vitro)	At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC50=0.33 μM) is comparable to its potency against RNA cleavage in vitro.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Sanches M, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (148.66 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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