Ifebemtinib|1227948-82-4|(BI-853520; IN-10018)-陌孚医药/Medlife

您当前的位置：

Ifebemtinib (Synonyms: BI-853520; IN-10018)

目录号: PL02566 纯度: ≥99%

CAS No. :1227948-82-4

商品编号	规格	价格	会员价
PL02566-5mg	5mg	¥6181.82	请登录
PL02566-10mg	10mg	¥10509.09	请登录
PL02566-50mg	50mg	询价	询价
PL02566-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Ifebemtinib
英文名称	Ifebemtinib
英文别名	Benzamide, 4-[[4-[(2,3-dihydro-2-methyl-3-oxo-1H-isoindol-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-;IN10018（BI853520）;IN10018;Ifebemtinib
Cas No.	1227948-82-4
分子式	C₂₈H₂₈F₄N₆O₄
分子量	588.55
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Ifebemtinib (BI 853520) 是一种具有口服活性的粘附斑激酶 (FAK) 强效抑制剂 (重组 FAK IC₅₀=1 nM)，Ifebemtinib 表现出对癌细胞的抗增殖活性。

生物活性

Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC 50 =1?nM). Ifebemtinib shows anti-proliferative activity against cancer cells.

性状

Solid

体外研究(In Vitro)

Ifebemtinib (BI 853520) (0-3 μM; 2 h) inhibits cancer cells growth.
Ifebemtinib (BI 853520) (0-30 μM; 4-6 d) represses tumor cell proliferation and invasion only in 3D culture.
Ifebemtinib (0-10 μM; 24 h) represses Y397-FAK autophosphorylation.
Ifebemtinib (0.1 μM; 96 h) shows a fast and potent inhibition of FAK in this highly metastatic murine breast cancer cell line. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Ifebemtinib (BI 853520) (oral gavage; 50 mg/kg; once daily; 0-8 weeks) treatment significantly suppresses primary tumor growth of all three cell lines in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Stefanie Tiede, et al. The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis. 2018 Sep 20;7(9):73.
[2]. Ulrich A Hirt, et al. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7(2):21.

溶解度数据	In Vitro: DMSO : 66.67 mg/mL (113.28 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation