7BIO|916440-85-2|(7-Bromoindirubin-3-Oxime)-陌孚医药/Medlife

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7BIO (Synonyms: 7-Bromoindirubin-3-Oxime)

目录号: PL02483 纯度: ≥98%

CAS No. :916440-85-2

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中文名称	7BIO
英文名称	7BIO
英文别名	7BIO;7-bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one;7-Bromoindirubin-3'-oxime;7-Bromoindirubin-3'Oxime;7-BIO;7-bromo-indirubin-3'-oxime;7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol;BDBM54685;cid_11846148;BDBM50012184;BDBM50191405;NSC737346;(2''Z,3''E)-7-bromoindirubin-3''-oxime;7-bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]-2-indolone;7-bromanyl-3-[3-(oxidanylamino)-1H-indol-2-yl]indol-2-one;7-Bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one (ACI)
Cas No.	916440-85-2
分子式	C₁₆H₁₀BrN₃O₂
分子量	356.17
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	7BIO (7-Bromoindirubin-3-Oxime) 是靛玉红的衍生物。7BIO (7-Bromoindirubin-3-Oxime) 对细胞周期蛋白依赖性激酶5 (CDK5) 和糖原合酶激酶-3β (GSK3β) 具有抑制作用。7BIO (7-Bromoindirubin-3-Oxime) 抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍^[1]。
生物活性	7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice.
性状	Solid
IC50 & Target[1][2]	CDK5 GSK3β
体外研究(In Vitro)	7BIO (1 and 10 μM; 24 hours) has neuroprotective effects and can prevent, but cannot rescue Aβ1?42 oligomer-induced cell death in SH-SY5Y cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) significantly attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) decreases Aβ oligomer-induced increase of TNF-α and IL-6 production in the brain and the expression of synapsin-1 and PSD-95 in the hippocampal region of mice. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) attenuates Aβ oligomer-induced increase expression of pTau, activation of microglia and astrogliosis in the brain of mice. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) prevents decreased expression of pSer9-GSK3β and has no significant effects on the Tau protein level. has not independently confirmed the accuracy of these methods.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Chen L, et al. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Front Mol Neurosci. 2017;10:393.

溶解度数据	In Vitro: DMSO : 250 mg/mL (701.91 mM; Need ultrasonic)Ethanol : 50 mg/mL (140.38 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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