(+)-Norfenfluramine hydrochloride|37936-89-3|-陌孚医药/Medlife

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(+)-Norfenfluramine hydrochloride

目录号: PL02358 纯度: ≥99%

CAS No. :37936-89-3

商品编号	规格	价格	会员价
PL02358-5mg	5mg	询价	询价
PL02358-10mg	10mg	询价	询价
PL02358-25mg	25mg	询价	询价
PL02358-50mg	50mg	询价	询价

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中文名称	(+)-Norfenfluramine hydrochloride
中文别名	S-(+)-Α-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE 盐酸盐;去甲芬氟拉明盐酸盐
英文名称	(+)-Norfenfluramine hydrochloride
英文别名	Benzeneethanamine, a-methyl-3-(trifluoromethyl)-,hydrochloride (1:1), (aS)-;(2S)-1-[3-(trifluoromethyl)phenyl]propan-2-amine,hydrochloride;(+)-Norfenfluramine hydrochloride;Benzeneethanamine,a-methyl-3-(trifluoromethyl)-,hydrochloride, (S)- (9CI);d-Norfenfluramine hydrochloride;Norfenfluraminehydrochloride;7LC49OH4I8;Norfenfluramine hydrochloride, (S)-;Tox21_501246;LP01246;S-(+)-;A-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride;S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride;Benzeneethanamine, alpha-methyl-3-;(S)-norfenfluramine hydrochloride;Q27268511;Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, hydrochloride, (S)-;(2S)-1-[3-(TRIFLUOROMETHYL)PHENYL]
Cas No.	37936-89-3
分子式	C₁₀H₁₃ClF₃N
分子量	239.67
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	(+)-Norfenfluramine hydrochloride 是 (+)-fenfluramine 的主要肝脏代谢物，是一种选择性的 5-HT_2B 受体激动剂 (K_i: 11.2 nM)。(+)-Norfenfluramine hydrochloride 有效地刺激磷酸肌醇的水解并增加细胞内 Ca²⁺。(+)-Norfenfluramine hydrochloride 可用于原发性肺动脉高压和心脏瓣膜病的研究。
生物活性	(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT 2B receptor agonist (K i : 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease.
性状	Solid
IC50 & Target[1][2]	5-HT2B Receptor 11.2 nM (Ki) 5-HT2C Receptor
体外研究(In Vitro)	(+)-Norfenfluramine (1 nM to 100 μM) hydrochloride contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats. (+)-Norfenfluramine (1 and 10 μM, 3 min) hydrochloride induces contraction in aorta from tissues of normotensive and hypertensive rats. (+)-Norfenfluramine (0-10 μM, 3 min) hydrochloride induces 5-HT release from rat hippocampal synaptosomes by Ca-dependent way . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats. (+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. [2]. M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7.

溶解度数据	In Vitro: H₂O : 18.75 mg/mL (78.23 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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