4-Hydroperoxy Cyclophosphamide-d4|1246816-71-6|-陌孚医药/Medlife

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4-Hydroperoxy Cyclophosphamide-d4

目录号: PL02343 纯度: ≥95%

CAS No. :1246816-71-6

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中文名称	4-Hydroperoxy Cyclophosphamide-d4
中文别名	[2H4]-4-过氧氢环磷酰胺[干冰运输]
英文名称	4-Hydroperoxy Cyclophosphamide-d4
英文别名	4-Hydroperoxy Cyclophosphamide-d4;N,N-bis(2-chloro-2,2-dideuterioethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine;[2H4]-4-Hydroperoxy Cyclophosphamide
Cas No.	1246816-71-6
分子式	C₇H₁₅Cl₂N₂O₄P
分子量	297.11
包装储存	-80°C, stored under nitrogen

产品详情	4-Hydroperoxy Cyclophosphamide-d₄ 是 4-Hydroperoxy cyclophosphamide 的氘代物。4-Hydroperoxy cyclophosphamide 是前药 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于死亡受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。
生物活性	4-Hydroperoxy Cyclophosphamide-d 4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-80°C, stored under nitrogen
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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