9-Cyclopentyladenine monomethanesulfonate (Synonyms: 9-CP-Ade mesylate)
目录号: PL02305 纯度: ≥99%
CAS No. :189639-09-6
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中文名称
9-Cyclopentyladenine monomethanesulfonate
中文别名
9-环戊基氨基嘌呤;(2-甲基-2-丙烯)琥珀酸酐;9-环戊基-9H-嘌呤-6-胺甲烷磺酸酯(1:1)
英文名称
9-Cyclopentyladenine monomethanesulfonate
英文别名
9-CYCLOPENTYLADENINE MONOMETHANESULFONATE;9-CP-Ade mesylate;9-Cyclopentyladenine mesylate;9-CP-Ade mesylate, 9-Cyclopentyladenine mesylate;9-cp-ade mesylate
Cas No.
189639-09-6
分子式
C10H13N5.CH4O3S
分子量
299.35
包装储存
-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
产品详情
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) 是一种稳定的非竞争性腺苷酸环化酶 (adenylate cyclase) 抑制剂,具有细胞渗透性。
生物活性
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties.
性状
Solid
体外研究(In Vitro)
9-Cyclopentyladenine monomethanesulfonate (200 μM, 30 min) inhibits the activation of cAMP response element binding protein (CREB) and completely blocks neurogenesis in PC12 cells.
9-Cyclopentyladenine monomethanesulfonate (100 μM, 30min) attenuates the effect of relaxin on mechanical activity and prevents relaxin-induced hyperpolarization thereby being involved in the regulation of relaxin on ileal smooth muscle activity in female CD1 Swiss mice.
9-Cyclopentyladenine monomethanesulfonate (100 μM, 6 hours) promotes restoration of the keratinocyte permeability barrier by inhibiting the synthesis of cAMP in male hairless mice.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. Ulrike Riese,et al. Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways. FEBS Lett. 2004 Nov 19;577(3):455-9.
[2]. Eglantina Idrizaj,et al. Relaxin influences ileal muscular activity through a dual signaling pathway in mice. World J Gastroenterol. 2018 Feb 28;24(8):882-893.
溶解度数据
In Vitro: DMSO : 41.67 mg/mL (139.20 mM; ultrasonic and warming and heat to 60°C)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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