9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties.
性状
Solid
体外研究(In Vitro)
9-Cyclopentyladenine monomethanesulfonate (200 μM, 30 min) inhibits the activation of cAMP response element binding protein (CREB) and completely blocks neurogenesis in PC12 cells.9-Cyclopentyladenine monomethanesulfonate (100 μM, 30min) attenuates the effect of relaxin on mechanical activity and prevents relaxin-induced hyperpolarization thereby being involved in the regulation of relaxin on ileal smooth muscle activity in female CD1 Swiss mice.9-Cyclopentyladenine monomethanesulfonate (100 μM, 6 hours) promotes restoration of the keratinocyte permeability barrier by inhibiting the synthesis of cAMP in male hairless mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. Ulrike Riese,et al. Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways. FEBS Lett. 2004 Nov 19;577(3):455-9.[2]. Eglantina Idrizaj,et al. Relaxin influences ileal muscular activity through a dual signaling pathway in mice. World J Gastroenterol. 2018 Feb 28;24(8):882-893.
溶解度数据
In Vitro: DMSO : 41.67 mg/mL (139.20 mM; ultrasonic and warming and heat to 60°C)配制储备液