WR99210|47326-86-3|(BRL 6231 free base)-陌孚医药/Medlife

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WR99210 (Synonyms: BRL 6231 free base)

目录号: PL02300 纯度: ≥98%

CAS No. :47326-86-3

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PL02300-200mg	200mg	询价	询价

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中文名称	WR99210
英文名称	WR99210
英文别名	6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine hydrochloride;1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine;WR99210;6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE;BRL 6231;1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-;WR 99210;6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine;1,6-Dihydro-6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)-propoxy)-1,3,5-triazine-2 ,4-diamine;1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-
Cas No.	47326-86-3
分子式	C₁₄H₁₈Cl₃N₅O₂
分子量	394.68
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	WR99210 是一种口服有效的、低毒的二氢叶酸还原酶 (DHFR) 抑制剂 (IC₅₀<0.075 nM)。WR99210 具有较好的抗寄生虫活性，能有效抑制间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine (HY-18062) 的恶性疟原虫株) 以及弓形虫。
生物活性	WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC 50 <0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii.
性状	Solid
IC50 & Target[1][2]	IC50: <0.075 nM (DHFR).
体外研究(In Vitro)	WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture. WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male mic
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

溶解度数据	In Vitro: DMSO : 5 mg/mL (12.67 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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