Benproperine phosphate|19428-14-9|(磷酸苯丙哌林)-陌孚医药/Medlife

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Benproperine phosphate (Synonyms: 磷酸苯丙哌林)

目录号: PL02234 纯度: ≥99%

CAS No. :19428-14-9

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中文名称	Benproperine phosphate
中文别名	磷酸苯丙哌林;1-[2-(2-苄基苯氧基)-1-甲基乙基]哌啶磷酸盐;咳快好（磷酸苯丙哌林）;磷酸苯丙哌啉;N-(2,3-二氢-1H-茚-2-基)-2,2,2-三氟乙酰胺;磷酸苯丙哌林溶液,100PPM;磷酸苯丙哌林原药粉生产厂家行情价格;磷酸苯丙哌啉 100MG
英文名称	Benproperine phosphate
英文别名	benproperine phosphate;1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine phosphate;Flaveric;Blascorid;ASA 158-5;Benproperine phospha;Trihydrogen phosphate;Benproperine Phosphater;BENPROPERINE PHOSPHATE CP2000;Benproperine phosphate Solution, 100ppm;1-[1-(2-benzylphenoxy)propan-2-yl]piperidine;磷酸苯丙哌林原药粉生产厂家行情价格;Pirexyl phosphate;Pirexyl;Benproperine trihydrogen phosphate;Benproperine phosphate [JAN];1-(1-Methyl-2-(2-benzylphenoxy)ethyl)piperidine phosphate;1-(2-Benzylphenoxy)-2-piperidinopropane phosphate;CPD000469294;1-(2-(2-Benzilfenossi)-1-metiletil)-piperidina fosfato [Italian];1-(1-Methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine phosphate;Benproperine phosphate (JAN);1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidinium dihydr
Cas No.	19428-14-9
分子式	C₂₁H₃₀NO₅P
分子量	407.44
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。
生物活性	Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.
性状	Solid
体外研究(In Vitro)	Benproperine phosphate (20-120 μM; for 24?hours) inhibits cell viability in a dose-dependent manner. Benproperine phosphate (10 μM; for 24?hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2?μM. Benproperine phosphate (10 μM; for 24?hours) does not affect cortactin-rich lamellipodium in MCF-10A cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Benproperine phosphate (50, 100?mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth. Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Yae Jin Yoon, et al. Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis. Biochem Pharmacol. 2019 May;163:46-59.

溶解度数据	In Vitro: DMSO : 250 mg/mL (613.59 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (245.43 mM)

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