Glutaminase-IN-1|2247127-79-1|(CB839 derivative)-陌孚医药/Medlife

您当前的位置：

Glutaminase-IN-1 (Synonyms: CB839 derivative)

目录号: PL02202 纯度: ≥98%

CAS No. :2247127-79-1

商品编号	规格	价格	会员价
PL02202-5mg	5mg	¥1483.64	请登录
PL02202-10mg	10mg	¥2349.09	请登录
PL02202-50mg	50mg	¥6800.00	请登录
PL02202-100mg	100mg	¥10509.09	请登录
PL02202-200mg	200mg	询价	询价
PL02202-500mg	500mg	询价	询价
PL02202-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2018.98	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Glutaminase-IN-1
英文名称	Glutaminase-IN-1
英文别名	Glutaminase-IN-1;CB839 derivative;BDBM50517275;N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-selenadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
Cas No.	2247127-79-1
分子式	C₂₆H₂₄F₃N₇O₃Se
分子量	618.47
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Glutaminase-IN-1 (CB839 derivative) 是CB839 的一个衍生物，是1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，其IC₅₀ 值为1 nM。Glutaminase-IN-1 (CB839 derivative) 具有提高细胞摄取和抗肿瘤的活性。
生物活性	Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC 50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
性状	Solid
IC50 & Target[1][2]	IC50: 1 nM (KGA).
体外研究(In Vitro)	Glutaminase-IN-1 (CPD20), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 shows improved cellular uptake and antitumor activity. The IC50 values of Glutaminase-IN-1 are 17 nM, 6.78 μM, 19 nM and 9 nM in A549, H2, Caki-1 and HCT116 cell lines, respectively. Glutaminase-IN-1 has better KGA inhibitory activity than the corresponding BPTES and CB839. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Glutaminase-IN-1(10 mg/kg, s.c.) reduced the size and weight of the HCT116 tumor, and statistical analysis showed that the 40% reduction in tumor weight by CPD20 is statistically significant. Glutaminase-IN-1 could statistically significantly prolong the survival of H22-bearing mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Chen Z, et al. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2018 Dec 13.

溶解度数据	In Vitro: DMSO : 125 mg/mL (202.11 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation