BA-53038B 是一种 HBV 核心蛋白变构调节剂 (CpAM)，与 HAP 口袋结合并调节 HBV 衣壳组装。BA-53038B 对乙型肝炎病毒 (HBV) 具有抗病毒活性，EC₅₀ 值为 3.32 μM。BA-53038B 可用于慢性乙型肝炎的研究。

BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC 50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.

Solid

EC 50: 3.32 μM (HBV)

BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM.
BA-53038B has cytotoxicity with CC50 value of >100 μM.
BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein.
BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly.
BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein.
BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket.
BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W). has not independently confirmed the accuracy of these methods.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zhang X, et al. Discovery of Novel Hepatitis B Virus Nucleocapsid Assembly Inhibitors. ACS Infect Dis. 2019 May 10;5(5):759-768.

In Vitro: DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic)配制储备液