UNC9994 hydrochloride|2108826-33-9|-陌孚医药/Medlife

您当前的位置：

UNC9994 hydrochloride

目录号: PL01901 纯度: ≥98%

CAS No. :2108826-33-9

商品编号	规格	价格	会员价
PL01901-1mg	1mg	¥4327.27	请登录
PL01901-5mg	5mg	¥8654.55	请登录
PL01901-10mg	10mg	¥13600.00	请登录
PL01901-50mg	50mg	询价	询价
PL01901-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	UNC9994 hydrochloride
英文名称	UNC9994 hydrochloride
英文别名	Benzothiazole, 5-[3-[4-(2,3-dichlorophenyl)-1-piperidinyl]propoxy]-, hydrochloride (1:1)
Cas No.	2108826-33-9
分子式	C₂₁H₂₃Cl₃N₂Os
分子量	457.84
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	UNC9994 hydrochloride 是一种功能选择性的 β-arrestin 偏向的多巴胺 D₂ 受体 (D₂R) 激动剂，可选择性激活 β- arresttin 招募和信号转导。对 D₂R 的 K_i 值为 79 nM。UNC9994 hydrochloride 也是 G_i 调节 cAMP 产生的拮抗剂和 D2R/β-arrestin-2 相互作用的部分激动剂。UNC9994 hydrochloride 具有稳定精神效果。
生物活性	UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D 2 receptor (D 2 R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K i of 79 nM for D 2 R. UNC9994 hydrochloride is also an antagonist of G i -regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity.
性状	Solid
IC50 & Target[1][2]	D3 Receptor 17 nM (Ki) D2 Receptor
体外研究(In Vitro)	UNC9994 hydrochloride induces D2-mediated β-arrestin-2 translocation with an EC50s of 6.1 nM and 448 nM in Tango assay and DiscoveRx assay, respectively. UNC9994 hydrochloride is an antagonist at 5HT2A and 5HT2B and an agonist at 5HT2C and 5HT1A. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	UNC9994 (2.0 mg/kg; i.p.; once) hydrochloride shows antipsychotic activity that is attenuated in β-arrestin-2 knockout mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J w
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Allen JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93.

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation