BIP-135|941575-71-9|-陌孚医药/Medlife

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BIP-135

目录号: PL01866 纯度: ≥99%

CAS No. :941575-71-9

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中文名称	BIP-135
中文别名	3-(5-溴-1-甲基-1H-吲哚-3-基)-4-(苯并呋喃-3-基)吡咯-2,5-二酮;左美洛昔芬
英文名称	BIP-135
英文别名	3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione;3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;BIP-135;3-(3-Benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (ACI);3-(1-Benzofuran-3-yl)-4-(5-bromo-1-methylindol-3-yl)pyrrole-2,5-dione;3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;BIP 135;3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Cas No.	941575-71-9
分子式	C₂₁H₁₃BrN₂O₃
分子量	421.24
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC₅₀ 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
生物活性	BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC 50 s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.
性状	Solid
IC50 & Target[1][2]	GSK-3α 16 nM (IC50) GSK-3β 21 nM (IC5
体外研究(In Vitro)	BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations. BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight). BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (148.37 mM; ultrasonic and warming and heat to 70°C)配制储备液

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