Insulin degludec|844439-96-9|-陌孚医药/Medlife

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Insulin degludec

目录号: PL01695 纯度: ≥99%

CAS No. :844439-96-9

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中文名称	Insulin degludec
英文名称	Insulin degludec
Cas No.	844439-96-9
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情

Insulin degludec 是一种超长效形式的胰岛素，用于治疗 1 型和 2 型糖尿病引起的高血糖。Insulin degludec 结合胰岛素受体的 IC₅₀ 值为 19.59 nM/L。Insulin degludec 可用于 1 型和 2 型糖尿病的研究。

生物活性

Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC 50 value of 19.59 nM/L for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.

性状

Solid

IC50 & Target[1][2]

IC50: 19.59 nM/L (insulin receptor)

体外研究(In Vitro)

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM/L.
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

ClinicalTrial

参考文献

[1]. Bataglini C, et al. Insulin degludec and glutamine dipeptide modify glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. J Appl Biomed. 2021 Dec;19(4):210-219.
[2]. Hartmann T, et al. Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function. Cardiovasc Diabetol. 2016 Jul

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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