Capzimin|2084868-04-0|-陌孚医药/Medlife

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Capzimin

目录号: PL01858 纯度: ≥99%

CAS No. :2084868-04-0

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中文名称	Capzimin
英文名称	Capzimin
英文别名	8,8′-Disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide);Capzimin
Cas No.	2084868-04-0
分子式	C₃₀H₂₄N₆O₂S₄
分子量	628.81
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Capzimin是有效的，特异性适中的，蛋白酶体异肽酶 Rpn11 抑制剂。
生物活性	Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.
性状	Solid
IC50 & Target[1][2]	Target: Rpn11
体外研究(In Vitro)	Capzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC50=30 μM, 4.5 μM and 2.3 μM respectively. Capzimin is screened against the NCI panel of 60 cancer cell lines. The median GI50 is 3.3 μM. Capzimin exhibits promising activity in leukemia cells including the SR and K562 cell lines (GI50 values of 0.67 μM and 1 μM respectively), as well as several solid tumor cell lines including NCI-H460 (non-small cell lung cancer; GI50= 0.7 μM) and MCF7 (breast cancer; GI50=1.0 μM). Immunoblotting for the processed form of caspase 3 and caspase-cleaved poly ADP-ribose polymerase in HCT116 cells confirm that Capzimin not only blocks cell growth, but also induces apoptosis. has not independently confirmed the accuracy of these me
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Li J, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May;13(5):486-493.

溶解度数据	In Vitro: DMSO : ≥ 55.67 mg/mL (88.53 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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