(R)-Posenacaftor (R)-PTI-801) sodium 是 Posenacaftor 的 R 对映异构体。Posenacaftor (PTI-801) 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂，可纠正 CFTR 蛋白的折叠和运输。Posenacaftor 用于囊性纤维化 (CF) 的研究。

(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF).

Solid

IC50: CFTR

Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the  CFTR  gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells.
Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Benjamin Kopp, et al. Compositions et procédés pour améliorer la fonction cftr dans des cellules affectées par la fibrose kystique. Patent WO2019156946.

In Vitro: DMSO : 38.33 mg/mL (81.99 mM; Need ultrasonic)配制储备液