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产品总数：60950
| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
|---|---|---|---|---|---|
| PL01814-5mg | 5mg | ¥989.09 | 请登录 |
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| PL01814-10mg | 10mg | ¥1730.91 | 请登录 |
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| PL01814-50mg | 50mg | ¥4698.18 | 请登录 |
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| PL01814-100mg | 100mg | ¥7665.45 | 请登录 |
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| PL01814-200mg | 200mg | 询价 | 询价 |
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| PL01814-500mg | 500mg | 询价 | 询价 |
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| PL01814-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥1088.00 | 请登录 |
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| 中文名称 |
CP-466722
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|---|---|
| 中文别名 |
1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺;CP466722 抑制剂;CP-466722
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| 英文名称 |
CP-466722
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| 英文别名 |
CP466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;CP-466722;cc-85;CP466722, CP-466722, ATM;HMS3265A19;HMS3265A20;HMS3265B19;S2245_Selleck;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-Triazol-5-amine
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| Cas No. |
1080622-86-1
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| 分子式 |
C17H15N7O2
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| 分子量 |
349.35
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| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
CP-466722 是一种可逆的 ATM 抑制剂，IC50 值为 4.1 μM，但对 PI3K，PIKK 家族蛋白没有作用。
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|---|---|---|---|
| 生物活性 |
CP-466722 is a rapidly reversible inhibitor of ATM, with an IC 50 of 4.1 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
ATM 4.1 μM (IC50)
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| 体外研究(In Vitro) |
CP-466722 (CP466722, 6-10 μM) inhibits IR-induced ATM kinase activity, and the inhibition can be rapidly and completely reversed. CP466722 (6, 10 μM) inhibits p53 induction and ATM-dependent phosphorylation in mouse cells, but CP466722 fails to inhibit ATR activity and ATR-dependent phosphorylation of Chk1. CP466722 (6 μM) disrupts ATM-dependent cell cycle checkpoints in cells. CP466722 (1 μM) completely inhibits ATM-dependent phosphorylation in MCF7 cells. CP466722 (10 μM) reduces pKAP1 phosphorylation in MCF7 cells, with an IC50 of 0.41 μM. CP466722 (10 μM) inhibits both pATM and pKAP1 signals. CP-466722 (CP466722, 5-50 μM) inhibits proliferation of SKBr-3 cancer cells more strongly than MCF-7 cancer cells. CP466722 (10 μM) also slightly increases proportions of MCF-7 and SKBr-3 cells in the G1 phase after treatment for 48 hours.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| 参考文献 |
[1]. Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74.[2]. Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19(4):538-46.[3].
搜索质检报告(COA)
1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。 2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。 相关产品更多
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