Tomeglovir|233254-24-5|(托美洛韦; BAY 38-4766)-陌孚医药/Medlife

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Tomeglovir (Synonyms: 托美洛韦; BAY 38-4766)

目录号: PL01657 纯度: ≥99%

CAS No. :233254-24-5

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PL01657-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1496.00	请登录

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中文名称	Tomeglovir
中文别名	托格韦尔;托美洛韦
英文名称	Tomeglovir
英文别名	Propanamide,N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-;BAY-38-4766;N-[4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)phenyl]-3-hydroxy-2,2-dimethylpropanamide;Tomeglovir;N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;BAY 38-4766
Cas No.	233254-24-5
分子式	C₂₃H₂₇N₃O₄S
分子量	441.54
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Tomeglovir 是一种抗 CMV 剂，能够抑制病毒 DNA 多联体的进程，对 HCMV 和 MCMV 的 IC₅₀ 值分别为 0.34 μM 和 0.039 μM。
生物活性	Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV.
性状	Solid
IC50 & Target[1][2]	IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)
体外研究(In Vitro)	Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57 μM and < 1 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Weber O, et al. Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo. Antiviral Res. 2001 Mar;49(3):179-89. [2]. Reefschlaeger J, et al. Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action. J Antimicrob Chemother. 2001 Dec;48(6):757-67.

溶解度数据	In Vitro: DMSO : ≥ 108 mg/mL (244.60 mM)配制储备液

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