WAY-213613 (hydrochloride) 是一种有效的选择性人 EAAT2 抑制剂。WAY-213613 具有有效的 EAAT2 抑制活性，IC₅₀ 值为 85 nM。WAY-213613 可用于中枢神经系统的研究。

WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC 50 value of 85 nM. WAY-213613 can be used for the research of central nervous system.

Solid

IC50: 5004 nM (EAAT1); 85 nM (EAAT2); 3787 nM (EAAT3)

WAY-213613 (hydrochloride) (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC50 values of 5004 nM, 85 nM and 3787 nM, respectively.
WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[H] glutamate uptake with Ki values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively.
WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- orEAAT3-injected oocytes, with IC50 values of 48, 0.13 and 4.0 μM, respectively.
WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
[2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimers disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.

In Vitro: DMSO : 50 mg/mL (110.71 mM; warming and heat to 80°C)H₂O : < 0.1 mg/mL (insoluble)配制储备液