HIV-1 integrase inhibitor 8|1568-80-5|-陌孚医药/Medlife

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HIV-1 integrase inhibitor 8

目录号: PL01618 纯度: ≥99%

CAS No. :1568-80-5

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中文名称	HIV-1 integrase inhibitor 8
中文别名	3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇;3,3,3',3'-四甲基-2,2',3,3'-四氢-1,1'-螺二[茚满]-6,6'-二醇;3,3,3’,3’-四甲基-2,2’,3,3’-四氢-1,1’-螺bi[茚]-6,6’-二醇;俗名SPIROBIINDANE 化学名 3,3,3',3'-tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
英文名称	HIV-1 integrase inhibitor 8
英文别名	1,1'-Spirobi[1H-indene]-6,6'-diol,2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-;2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol;5-PHENYL-2,2'-BIPYRIDINE;SPIROBIINDANE;2,2',3,3'-TETRAHYDRO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBI-1H-INDENE- 6,6'-DIOL;tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol;Spiro Biindane Bisphenol;BDBM176762;US9688816, 5;1,1,1',1'-Tetramethyl-3,3'-spirobi[3a,7a-dihydro-2H-indene]-5,5'-diol;HIV-1 integrase inhibitor 8
Cas No.	1568-80-5
分子式	C₂₁H₂₈O₂
分子量	312.45
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，化合物 8。
生物活性	HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
性状	Solid
体外研究(In Vitro)	HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn as the cationic cofactor by gel assay with IC50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 μM. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3, 3-tetramethyl-1,1-spirobi(indan)-5,5,6,6-tetrol Family.J Med Chem

溶解度数据	In Vitro: DMSO : 125 mg/mL (405.30 mM; Need ultrasonic)配制储备液

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