B I09|1607803-67-7|-陌孚医药/Medlife

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B I09

目录号: PL01606 纯度: ≥99%

CAS No. :1607803-67-7

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中文名称	B I09
中文别名	化合物 T14847
英文名称	B I09
英文别名	B I09;7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one;5H-[1]Benzopyrano[3,4-c]pyridin-5-one, 7-(1,3-dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-
Cas No.	1607803-67-7
分子式	C₁₆H₁₇NO₅
分子量	303.31
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	B I09 是 IRE-1 核糖核酸酶的一个抑制剂，其 IC₅₀ 值为 1230 nM。
生物活性	B I09 is an IRE-1 RNase inhibitor, with an IC 50 of 1230 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 1230 nM (IRE-1 RNase).
体外研究(In Vitro)	B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301. [2]. Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124(6):2585-98.

溶解度数据	In Vitro: DMSO : 8.33 mg/mL (27.46 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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