Caroverine hydrochloride|55750-05-5|(Tinnex hydrochloride)-陌孚医药/Medlife

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Caroverine hydrochloride (Synonyms: Tinnex hydrochloride)

目录号: PL01572 纯度: ≥96%

CAS No. :55750-05-5

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中文名称	Caroverine hydrochloride
中文别名	Caroverine盐酸
英文名称	Caroverine hydrochloride
英文别名	2(1H)-Quinoxalinone,1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1);1-[2-(DIETHYLAMINO)ETHYL]-3-[(4-METHOXYPHENYL)METHYL]-2(1H)-QUINOXALINONE MONOHYDROCHLORIDE;1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one,hydrochloride;Caroverine HCl;Caroverine hydrochloride;1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride
Cas No.	55750-05-5
分子式	C₂₂H₂₇N₃O₂^.HCl
分子量	401.93
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Caroverine (Tinnex) hydrochloride 是一种有效，竞争性和可逆的 NMDA 和 AMPA 谷氨酸受体拮抗剂。Caroverine hydrochloride 也是一种抗氧化剂和钙阻断剂，具有血管舒张作用。Caroverine hydrochloride 可用于内耳耳鸣的研究。
生物活性	Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.
性状	Solid
IC50 & Target[1][2]	NMDA AMPA
体外研究(In Vitro)	Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats of eithe
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. [2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.

溶解度数据	In Vitro: DMSO : 100 mg/mL (248.80 mM; Need ultrasonic)H₂O : 20 mg/mL (49.76 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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