PMEDAP|113852-41-8|-陌孚医药/Medlife

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PMEDAP

目录号: PL01564 纯度: ≥98%

CAS No. :113852-41-8

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中文名称	PMEDAP
英文名称	PMEDAP
英文别名	Phosphonic acid,P-[[2-(2,6-diamino-9H-purin-9-yl)ethoxy]methyl]-;2-(2,6-diaminopurin-9-yl)ethoxymethylphosphonic acid;9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine;((2-(2,6-Diamino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid;{[2-(2,6-diamino-9h-purin-9-yl)ethoxy]methyl}phosphonic acid;2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine;5-(3-Hydroxy-2-phosphonomethoxypropyladenine);9-(2-phosphonomethoxyethyl)-2,6-diaminopurine;N-(2-Phosphonomethoxyethyl)-2,6-diaminopuri;Phosphonic acid, ((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)-;Pmedap;PME-DAP
Cas No.	113852-41-8
分子式	C₈H₁₃N₆O₄P
分子量	288.20
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	PMEDAP 是人类免疫缺陷病毒 (HIV) 复制的有效抑制剂。PMEDAP 具有抗小鼠巨细胞病毒 (MCMV) 活性。PMEDAP 是莫罗尼鼠肉瘤病毒 (MSV) 诱导的肿瘤形成和相关死亡率的有效抑制剂。
生物活性	PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality.
性状	Solid
体内研究(In Vivo)	PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbio [2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):10

溶解度数据	In Vitro: 0.1 M NaOH : 14.29 mg/mL (49.58 mM; ultrasonic and adjust pH to 12 with NaOH)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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