DL-Buthionine-(S,R)-sulfoximine|5072-26-4|(Buthionine sulfoximine; BSO)-陌孚医药/Medlife

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DL-Buthionine-(S,R)-sulfoximine (Synonyms: Buthionine sulfoximine; BSO)

目录号: PL01561 纯度: ≥98%

CAS No. :5072-26-4

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中文名称	DL-Buthionine-(S,R)-sulfoximine
中文别名	DL-(3-氨基-4-羧丙基)-(S,R)-丁基硫氧亚胺;丁基硫;DL-丁硫氨酸亚砜;丁硫氨酸-亚砜亚胺;DL-丁硫氨酸(S,R)-亚砜亚胺;DL-丁硫氨酸-(S,R)-亚砜亚胺;丁硫胺酸亚砜胺(BSO)
英文名称	DL-Buthionine-(S,R)-sulfoximine
英文别名	Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-;DL-Buthionine-[S,R]-Sulfoximine;2-amino-4-(butylsulfonimidoyl)butanoic acid;D,L-Buthionine-(S,R)-sulfoximine;DL -BUTHIONINE-S,R-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine;DL-Buthionine-(S,R)-sulfoximine;Buthionine sulfoximine;BSO
Cas No.	5072-26-4
分子式	C₈H₁₈N₂O₃S
分子量	222.31
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

DL-Buthionine-(S,R)-sulfoximine 是谷氨酰半胱氨酸合成酶生物合成 (glutamylcysteine synthetase biosynthesis) 的有效抑制剂。

生物活性

DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

性状

Solid

IC50 & Target[1][2]

glutamylcysteine synthetase

体外研究(In Vitro)

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.
[2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.

溶解度数据	In Vitro: H₂O : 25 mg/mL (112.46 mM; ultrasonic and warming and heat to 60°C)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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