DL-Buthionine-(S,R)-sulfoximine hydrochloride||(Buthionine sulfoximine hydrochloride; BSO hydrochloride)-陌孚医药/Medlife

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DL-Buthionine-(S,R)-sulfoximine hydrochloride (Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride)

目录号: PL01562 纯度: ≥98%

商品编号	规格	价格	会员价	是否有货	数量
PL01562-50mg	50mg	¥741.82	请登录
PL01562-10mM*1mLinDMSO	10mM*1mLinDMSO	¥816.00	请登录

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中文名称	DL-Buthionine-(S,R)-sulfoximine hydrochloride
英文名称	DL-Buthionine-(S,R)-sulfoximine hydrochloride
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) 是谷氨酰半胱氨酸合成酶生物合成的有效抑制剂。

生物活性

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

性状

Solid

IC50 & Target[1][2]

Glutamylcysteine synthetase

体外研究(In Vitro)

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.
[2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.

溶解度数据	In Vitro: H₂O : ≥ 140 mg/mL (541.02 mM)DMSO : ≥ 125 mg/mL (483.05 mM)Ethanol : 25 mg/mL (96.61 mM; Need ultrasonic)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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