IMD-0560|439144-66-8|-陌孚医药/Medlife

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IMD-0560

目录号: PL01526 纯度: ≥99%

CAS No. :439144-66-8

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中文名称	IMD-0560
中文别名	N-[2,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide
英文名称	IMD-0560
英文别名	N-[2,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide;419X829330;Benzamide, N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxy-;Q27258424;5-Bromo-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide;IMD-0560
Cas No.	439144-66-8
分子式	C₁₅H₈BrF₆NO₂
分子量	428.12
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	IMD-0560 是一个新型的 IκB kinase β 抑制剂。
生物活性	IMD-0560 is a novel IκB kinase β inhibitor.
性状	Solid
IC50 & Target[1][2]	IKKβ
体外研究(In Vitro)	Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.

溶解度数据	In Vitro: Ethanol : 50 mg/mL (116.79 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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