Melflufen hydrochloride|380449-54-7|(Melphalan flufenamide hydrochloride)-陌孚医药/Medlife

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Melflufen hydrochloride (Synonyms: Melphalan flufenamide hydrochloride)

目录号: PL01502 纯度: ≥99%

CAS No. :380449-54-7

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中文名称	Melflufen hydrochloride
英文名称	Melflufen hydrochloride
英文别名	J-1 hydrochloride;Melflufen (hydrochloride);Melphalan flufenamide hydrochloride;3412470A0V;Melphalan flufenamide hydrochloride (USAN);Melphalan flufenamide hydrochloride [USAN];Melflufen hydrochloride;CK 1535;D11870;Melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride;L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-L-phenylalanyl-4-fluoro-, ethyl ester, monohydrochloride;Ethyl 4-[bis(2-chloroethyl)amino]-L-phenylalanyl-4-fluoro-L-phenylalaninate hydrochloride (1:1);J1 hydrochloride;Melphalan-flufenamide
Cas No.	380449-54-7
分子式	C₂₄H₃₁Cl₃FN₃O₃
分子量	534.88
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Melflufen (Melphalan flufenamide) hydrochloride，Melphalan 的一种二肽前体药物，是一种烷基化剂。Melflufen hydrochloride 对多发性骨髓瘤细胞具有抗肿瘤活性，并抑制血管生成。Melflufen hydrochloride 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。

生物活性

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells.

性状

Solid

体外研究(In Vitro)

Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.
Melflufen hydrochloride induces apoptosis in MM.1S cells.
Melflufen hydrochloride also is a potent activator of exosome secretion.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031.
[2]. Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (62.31 mM; Need ultrasonic)H₂O : 1 mg/mL (1.87 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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