N-Arachidonylglycine|179113-91-8|(NA-Gly)-陌孚医药/Medlife

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N-Arachidonylglycine (Synonyms: NA-Gly)

目录号: PL01401 纯度: ≥98%

CAS No. :179113-91-8

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中文名称	N-Arachidonylglycine
中文别名	4-甲硫基苯乙酮;N-花生四烯酰基甘氨酸
英文名称	N-Arachidonylglycine
英文别名	Glycine,N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-;Arachidonoyl Glycine;N-ARACHIDONYLGLYCINE;N-Arachidonylglycine,N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine;N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine;NAGLY;N-Arachidonoylglycine;Arachidonyl Glycine;NAGly, CID 5283389;N-Arachidonoyl glycine (solution in ethanol);N-ARACHIDONYL GLYCINE;N-ARACHIDONOYL GLYCINE
Cas No.	179113-91-8
分子式	C₂₂H₃₅NO₃
分子量	361.52
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	N-Arachidonylglycine (NA-Gly) 是内源性大麻素类 anandamide (AEA) 的羧基类似物，是一种 GPR18 激动剂 (EC₅₀ = 44.5 nM)。与 AEA 不同，N-Arachidonylglycine 在 CB1 和 CB2 受体上均无活性。N-Arachidonylglycine 可抑制 GLYT2 (IC₅₀ = 5.1 μM)。 N-Arachidonylglycine 也是子宫内膜细胞迁移的有效激活剂。
生物活性	N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC 50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC 50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
性状	Oil
IC50 & Target[1][2]	GlyT2 5.1 μM (IC50)
体外研究(In Vitro)	N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells. N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis-tbl"> <
体内研究(In Vivo)	N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold. N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. McHugh D, et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012;165(8):2414-2424. [2]. Edington AR, et al. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J Biol Chem. 2009;284(52):36424-36430.

溶解度数据	In Vitro: DMSO : 50 mg/mL (138.30 mM; Need ultrasonic)配制储备液

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