AKT Kinase Inhibitor hydrochloride||-陌孚医药/Medlife

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AKT Kinase Inhibitor hydrochloride

目录号: PL01358 纯度: ≥99%

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中文名称	AKT Kinase Inhibitor hydrochloride
英文名称	AKT Kinase Inhibitor hydrochloride
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	AKT Kinase Inhibitor hydrochloride 是一种具有抗肿瘤活性的 Akt 抑制剂。
生物活性	AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity.
性状	Solid
体外研究(In Vitro)	The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

溶解度数据	In Vitro: DMSO : 3.33 mg/mL (8.46 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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