AKT Kinase Inhibitor|842148-40-7|-陌孚医药/Medlife

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AKT Kinase Inhibitor

目录号: PL01357 纯度: ≥98%

CAS No. :842148-40-7

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中文名称	AKT Kinase Inhibitor
中文别名	AKT 激酶抑制剂
英文名称	AKT Kinase Inhibitor
英文别名	3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-propyn-1-ol;2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-;3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-...;3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]prop-2-yn-1-ol;AKT Kinase Inhibitor
Cas No.	842148-40-7
分子式	₃₅₇^.₃₇
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂。
生物活性	AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
性状	Solid
体外研究(In Vitro)	The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

溶解度数据	In Vitro: DMSO : 16.67 mg/mL (46.65 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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