Ac-Gly-BoroPro是选择性的 FAP 抑制剂，K_i 值为23 nM。

Ac-Gly-BoroPro is a selective FAP inhibitor with a K i of 23 nM.

Solid

Ki: 23 nM (FAP)

FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (Ki=23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (Ki=377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with Ki values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, maki

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

Ac-G-{boroP}

[1]. Edosada CY, et al. Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity. J Biol Chem. 2006 Mar 17;281(11):7437-44.

In Vitro: DMSO : ≥ 50 mg/mL (233.61 mM)配制储备液