GSK682753A|1334294-76-6|-陌孚医药/Medlife

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GSK682753A

目录号: PL01193 纯度: ≥99%

CAS No. :1334294-76-6

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中文名称	GSK682753A
英文名称	GSK682753A
英文别名	GSK682753A;GSK-682753A;8-[(E)-3-(4-Chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one;EBI2 inhibitor GS682753A
Cas No.	1334294-76-6
分子式	C₂₃H₂₁Cl₃N₂O₃
分子量	479.78
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC₅₀值为 53.6 nM。
生物活性	GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC 50 of 53.6 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 53.6 nM (EBI2)
体外研究(In Vitro)	GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC50of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Benned-Jensen T, et al. Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011 Aug 19;286(33):29292-302.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (208.43 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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