MSDC 0160|146062-49-9|(米格列酮; Mitoglitazone; CAY10415)-陌孚医药/Medlife

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MSDC 0160 (Synonyms: 米格列酮; Mitoglitazone; CAY10415)

目录号: PL01090 纯度: ≥98%

CAS No. :146062-49-9

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中文名称	MSDC 0160
中文别名	CAY10415 抑制剂;匹格列酮;酸雾抑制剂
英文名称	MSDC 0160
英文别名	Mitoglitazone;5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione;CAY10415;MSDC-0160;CAY-10415;MSDC0160;5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-Thiazolidinedione;MSDC-0160(CAY10415);CAY10415 (Mitoglitazone);2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-;CAY 10415;MSDC 0160;5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione;US9562012, mitoglitazone;Mitoglitazone, >=98% (HPLC);IRNJSRAGRIZIHD-UHFFFAOYSA-N;BDBM228129;BCP16099;s7453;2;MDHB
Cas No.	146062-49-9
分子式	C₁₉H₁₈N₂O₄S
分子量	370.42
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

MSDC 0160 (Mitoglitazone) 是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂，也是线粒体丙酮酸载体 (MPC) 的调节剂。MSDC 0160 是一种噻唑烷二酮 (TZD)，具有抗糖尿病和神经保护活性作用。MSDC 0160 具有用于阿尔茨海默氏病的潜力。

生物活性

MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease.

性状

Solid

体外研究(In Vitro)

MSDC 0160 (Mitoglitazone; 1-50 μM; for 24 hours) significantly decreases phosphorylation of mTOR at 20 and 50 μM.
MSDC 0160 acts as insulin sensitizers without activating PPARγ.
MSDC 0160 (10 μM; pretreatment 1 hour) prevents the MPP (10 μM)-induced loss of both tyrosine hydroxylase (TH)-immunoreactive differentiated Lund human mesencephalic (LUHMES) cells.
MSDC 0160 (10 or 100 μM) prevents the loss of GFP-fluorescent dopaminergic neurons induced by MPP (0.75 mM) in nematodes.
MSDC 0160 (10-20 μM) in conbination with IGF-1 prevents the loss of insulin content and maintains insulin secretion.
MSDC 0160 (1-50 μM) treatment maintains human β-cell phenotype. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

MSDC 0160 (Mitoglitazone; 30 mg/kg; oral gavage; daily; for 7 days) improves locomotor behavior, increases survival of nigral dopaminergic neurons, boosts striatal dopamine levels, and reduces neuroinflammation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Rohatgi N, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One. 2013 May 1;8(5):e62012.
[2]. Ghosh A, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration inexperimental models of Parkinsons disease. Sci Transl Med. 2016 Dec 7;8(368):368ra174.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (89.98 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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