DTP3 TFA||-陌孚医药/Medlife

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DTP3 TFA

目录号: PL01088 纯度: ≥98%

商品编号	规格	价格	会员价
PL01088-5mg	5mg	¥1978.18	请登录
PL01088-10mg	10mg	¥3461.82	请登录
PL01088-25mg	25mg	¥4945.45	请登录
PL01088-50mg	50mg	¥6800.00	请登录
PL01088-100mg	100mg	¥9890.91	请登录
PL01088-200mg	200mg	询价	询价
PL01088-500mg	500mg	询价	询价
PL01088-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2783.05	请登录

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中文名称	DTP3 TFA
英文名称	DTP3 TFA
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	DTP3 TFA 是一种有效且选择性的 GADD45β/MKK7 抑制剂。DTP3 TFA 靶向 NF-κB 途径下游，具有抗癌活性。
生物活性	DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.
性状	Solid
IC50 & Target[1][2]	GADD45β/MKK7
体外研究(In Vitro)	DTP3 (10 μM; 1-21 days) causes the potent and tumor-selective induction of JNK activation and apoptosis, as shown by the appearance of phosphorylated JNK, as early as 24 hours. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	DTP3 TFA (s.c.; 14.5 mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, and virtually eradicates established subcutaneous myeloma xenografts in mice. DTP3 TFA (intravenous injection; 10 mg/kg/day) has t 1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and V d of 2.80 L/kg. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
参考文献	[1]. Tornatore L, et al. Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019 Apr 19;6:369-379. [2]. Tornatore L, et al. Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors. Cancer Cell. 2014 Oct 13;26(4):495-508.

溶解度数据	In Vitro: H₂O : 100 mg/mL (156.34 mM; Need ultrasonic)DMSO : 50 mg/mL (78.17 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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