LY2365109 hydrochloride
目录号: PL01062 纯度: ≥98%
CAS No. :1779796-27-8
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中文名称
LY2365109 hydrochloride
英文名称
LY2365109 hydrochloride
英文别名
LY2365109 (hydrochloride);LY 2365109 hydrochloride;LY-2365109 hydrochloride;LY2365109 hydrochloride;LY2365109 HCl;2-[2-[4-(1,3-benzodioxol-5-yl)-2-tert-butylphenoxy]ethyl-methylamino]acetic acid;hydrochloride;HMS3748E15;BCP32606;D84043;N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
Cas No.
1779796-27-8
分子式
C22H28ClNO5
分子量
421.91
包装储存
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
产品详情
LY2365109 hydrochloride 是一种高效、选择性的 GlyT1 抑制剂,抑制过表达 hGlyT1 细胞摄取谷氨酸的 IC50 值为 15.8 nM.
生物活性
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC 50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
性状
Solid
IC50 & Target[1][2]
hGlyT1 15.8 nM nM (IC50)
体内研究(In Vivo)
LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
LY2365109 hydrochloride increases seizure thresholds in mice.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
[2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
溶解度数据
In Vitro: DMSO : ≥ 31 mg/mL (73.48 mM)H2O : < 0.1 mg/mL (insoluble)
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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