B220|112228-65-6|-陌孚医药/Medlife

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B220

目录号: PL01044 纯度: ≥99%

CAS No. :112228-65-6

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

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中文名称	B220
英文名称	B220
英文别名	6H-Indolo[2,3-b]quinoxaline-6-ethanamine,N,N,2,3-tetramethyl-;B 220;2-(2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-6-yl)-N,N-dimethylethanamine;Rat Anti Mouse B220 (CD45R);B220
Cas No.	112228-65-6
分子式	C₂₀H₂₂N₄
分子量	318.42
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	B220 是一种能抑制 HSV-1，HSV-2 和人巨细胞病毒 (CMV) 生长的抗病毒剂。
生物活性	B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).
性状	Solid
IC50 & Target[1][2]	HSV-1 HSV-2
体外研究(In Vitro)	B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV). B220 inhibits neutrophil release of reactive oxygen species, as well as intracellular generation of reactive oxygen species. The inhibition is not achieved through direct oxygen radical scavenger activity of B220, and B220 has no immediate effects on the activity of the assembled oxidase. The neutrophil capability to phagocytose fluorescein-labeled opsonized yeast cells is reduced by B220. Cells preincubated with B220 (10 μg/mL) and then stimulated with the formylated peptide fMLP mobilize fewer C3 receptors on their surface than the control cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mohammed Homman, et al. Pharmaceutical formulation of B220 for topical treatment of herpes. EP 2489354 A1. [2]. Harbecke O, et al. The synthetic non-toxic drug 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline inhibits neutrophil production of reactive oxygen species. J Leukoc Biol. 1999 Jun;65(6):771-7.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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