A-205804|251992-66-2|-陌孚医药/Medlife

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A-205804

目录号: PL01040 纯度: ≥98%

CAS No. :251992-66-2

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中文名称	A-205804
中文别名	4-((4-甲基苯基)硫基)噻吩并(2,3-c)吡啶-2-甲酰胺;4-[(4-甲基苯基)硫基]噻吩并[2,3-C]吡啶-2-甲酰胺;A-205804 抑制剂;i>]吡啶-2-甲酰胺;4-[(4-甲基苯基)硫基]噻吩并[2,3-c]吡啶-2-甲酰胺
英文名称	A-205804
英文别名	A 205804;4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide;A-205804;4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide;A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide;HMS3269O07;UNII-TP7TB1SSZD;TP7TB1SSZD;4-(p-Tolylsulfanyl)thieno[2,3-c]pyridine-2-carboxamide;C15H12N2OS2;4-((4-Methylphenyl)thio)thieno(2,3-C)pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;Thieno(2,3-C)pyridine-2-carboxamide, 4-((4-methylphenyl)thio)-;HMS3;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Cas No.	251992-66-2
分子式	C₁₅H₁₂N₂Os₂
分子量	300.40
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	A-205804 是抑制 E-selectin 和 ICAM-1 表达的口服有效的，高效、选择性的先导抑制剂，对 E-selectin 和 ICAM-1 作用的 IC₅₀ 分别为 20 nM 和 25 nM。A-205804 可用于慢性炎症疾病的研究。
生物活性	A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC 50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases.
性状	Solid
IC50 & Target[1][2]	IC50: 20 nM (E-selectin), 25 nM (ICAM-1)
体外研究(In Vitro)	A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of 152 μM. A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat. A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Stewart AO, et al. Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem. 2001 Mar 15;44(6):988-1002. [2]. Morita K, et al. RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. Blood Adv. 2018 Mar 13;2(5):509-515.

溶解度数据	In Vitro: DMSO : 100 mg/mL (332.89 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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