Bay 41-4109|298708-81-3|-陌孚医药/Medlife

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Bay 41-4109

目录号: PL01020 纯度: ≥98%

CAS No. :298708-81-3

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PL01020-200mg	200mg	询价	询价
PL01020-500mg	500mg	询价	询价

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中文名称	Bay 41-4109
中文别名	(4R)-4-(2-氯-4-氟苯基)-2-(3,5-二氟-2-吡啶基)-1,4-二氢-6-甲基-5-嘧啶羧酸甲酯;Bay 41-4109
英文名称	Bay 41-4109
英文别名	(-)-4(R)-(2-Chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid methyl ester;BAY-41-4109;methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;Bay41-4109;Bayer 41-4109;Bay 41-4109;(4R)-4-(2-Chloro-4-fluorophényl)-2-(3,5-difluoro-2-pyridinyl)-6-méthyl-1,4-dihydro-5-pyrimidinecarboxylate de méthyle;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-;Methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidinecarboxylate;Methyl-(4R)-4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidincarboxylat;(4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid methyl ester;(4R)-4-(2-chloro-4-fluoro-phenyl)-2-(3,5-difluoro-2-pyridyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid methyl ester;methyl (4R)-4-(2-chloro-4-fluoro-phenyl)-2-(3,5-difluoro-2-pyridyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;methyl (4R)-4-(2-chloro-4-fluoro-phenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Cas No.	298708-81-3
分子式	C₁₈H₁₃ClF₃N₃O₂
分子量	395.76
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	BAY 41-4109是人乙型肝炎病毒 (HBV) 的有效抑制剂，IC₅₀值为 53 nM。
生物活性	BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC 50 of 53 nM.
性状	Solid
IC50 & Target[1][2]	IC50&Target: 53 nM (HBV)
体外研究(In Vitro)	BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. [2]. Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8.

溶解度数据	In Vitro: DMSO : 100 mg/mL (252.68 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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