Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. The product is unstable in solution and is recommended to be dispensed now.

方法：大鼠 β 胰岛素瘤细胞 Rin-5F 用 Streptozocin (1-10 mM) 处理 2-48 h，使用 MTT assay 检测细胞活力。
结果：在用 10 mM Streptozocin 处理 24 h 和 48 h 的细胞中观察到最大的抑制 (60-70%)。[1]
方法：神经干细胞用 Streptozocin (2.5 mM) 处理 2 天，使用 RT-qPCR 检测基因表达。
结果：Streptozocin 显著降低了 46.4% 的 GLUT3 mRNA 的相对表达水平，不影响 IR 和 GLUT1 的相对表达水平。[2]
方法：将 Streptozocin (40 mg/kg in the 50 mM sodium citrate buffer (pH 4.5)，现配现用) 腹腔注射给 C57BL/6 或 CD-1 male 小鼠，每天一次，持续五天。给药期间提供正常食物和 10% 蔗糖水，第六天用普通水代替 10% 蔗糖水。
结果：重复低剂量 Streptozocin 诱导小鼠 1 型糖尿病。[3]
方法：将 Streptozocin (200 mg/kg in the 50 mM sodium citrate buffer (pH 4.5)，现配现用) 单次腹腔注射给 C57BL/6 或 CD-1 male 小鼠。给药后提供正常食物和 10% 蔗糖水，第三天用普通水代替 10% 蔗糖水。
结果：单次高剂量 Streptozocin 诱导小鼠 1 型糖尿病。[3]

keep away from direct sunlight,keep away from moisture,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice.

1.Nahdi AMTA, et al. Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells. Oxid Med Cell Longev. 2017;2017:7054272.
2.Sun P, et al. Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells in Vitro-Correlation With Alterations in the Expression of Proteins Associated With the Insulin System. Front Aging Neurosci. 2018 May 18;10:145.
3.Furman BL. Streptozotocin-Induced Diabetic Models in Mice and Rats. Curr Protoc Pharmacol. 2015 Sep 1;70:5.47.1-5.47.20.
4.Iwase M, et al. Tohoku J Exp Med, 1989, 159(2), 83-90.
5.Acer S, et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):222-5.

H2O: 113.3 mg/mL (427.19 mM), Sonication and heating are recommended. DMSO: 16.67 mg/mL (62.84 mM), Sonication is recommended.(The compound is unstable in solution, please use soon.)