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2-茨醇；冰片；龙胆 (Synonyms: (±)-Borneol)

目录号: PC76991 纯度: ≥98%

DL-Borneol是D-Borneol和L-Borneol的外消旋混合物。DL-Borneol在中国广泛用于心血管和脑血管疾病的治疗。

CAS No. :507-70-0

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中文名称	2-茨醇；冰片；龙胆
中文别名	京尼平甙;栀子甙;去羟基栀子甙;枝子苷,京尼平苷;栀子苷(京尼平苷);栀子苷;栀子提取物栀子多糖;京尼平苷;栀子苷（别名：京尼平苷）;1-乙基-哌嗪-2-酮;Geniposide 京尼平甙;WAKO071-05071京尼平甙;结晶栀子甙;京尼平甙栀子苷;京尼平甙 Geniposide;京尼平甙(P);京尼平甙,Geniposid;京尼平苷,Geniposide,植物提取物,标准品,对照品;京尼平苷酸;栀子甙对照品;栀子苷标准品;栀子苷-京尼平苷;栀子提取物;酯蟾毒配基;桅子提取物;丹参酮2A;分析对照品;金龟莲提取物;京尼平苷 Geniposide;齐墩果;栀子甙,栀子苷;栀子苷(标准品);栀子苷(京尼平苷,去羟基栀子甙,枝子苷);栀子苷，京尼平苷
英文名称	Borneol
英文别名	Geniposid;GENIPOSIDE;Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-,methyl ester, (1S,4aS,7aS)-;(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester;1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester;Olea europaea L;GENIPOSIDE(P) PrintBack;Gardenoside;Gardenia Augusta Extract;Genipin 1-glucoside;Geniposidic;Jasminoidin;(1S,4αS,7αS)- 1-(β-D-Glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)- cyclopenta[c]pyran-4-carboxylic acid methyl ester;(1S)-1α-(β-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4a α,5,7a α-tetrahydrocyclopenta[c]pyran-4-carboxylic Acid Methyl Ester;Methyl (1S)-1α-(β-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c]pyran-4-carboxylate;[ "" ];Methyl (4aR,7aR)-7-(hydroxymethyl)-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetr;145295QLXY;methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate;Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)-;methyl (1S,4aS,7aR)-7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy
Cas No.	507-70-0
分子式	C₁₀H₁₈O
分子量	154.25
包装储存	Powder -20°C 3 years\|4°C 2 years In solvent -80°C 2 years\|-20°C 1 year

产品详情	DL-Borneol是D-Borneol和L-Borneol的外消旋混合物。DL-Borneol在中国广泛用于心血管和脑血管疾病的治疗。
生物活性	DL-Borneol is a racemic mixture of D-Borneol and L-Borneol. DL-Borneol is widely used for the treatment of cardiovascular and cerebrovascular diseases in China.
性状	固体
IC50 & Target[1][2]	Human Endogenous Metabolite
体外研究(In Vitro)	DL-Borneol increases intracellular accumulation of Rho123, and enhances P-gp substrates across the BBB in vitro, and also depresses mdr1a mRNA and P-gp expression. Furthermore, DL-Borneol could activate NF-κB and inhibition of NF-κB with MG132 and SN50 obscures the P-gp decreases induced by DL-Borneol. 10 μg/mL and 20 μg/mL DL-Borneol significantly increase phosphorylation of IκB expression at 30 min after treatment transiently. DL-Borneol treatment decreases P-gp expression in BMECs[1].
体内研究(In Vivo)	DL-Borneol significantly suppresses the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling are ameliorated in DL-Borneol-treated animals which is indicated by decreased LPO and increased SOD, GSH, CAT levels. The distinct neuronal damage observed in the kindled group is counteracted by DL-Borneol. Furthermore, it decreases the levels of GFAP which is manifested by reduced immunostaining[2]. The pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of DL-Borneol and that there are some components in Xingnaojing inhibiting the absorption of DL-Borneol[3].
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years\|4°C 2 years In solvent -80°C 2 years\|-20°C 1 year
结构分类	Others
来源	植物豆科锦鸡儿植物菊科
参考文献	[1]. Fan X, et al. Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Int J Mol Sci. 2015 Nov 18;16(11):27576-88. [Content Brief] [2]. Tambe R, et al. Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice. Naunyn Schmiedebergs Arch Pharmacol. 2016 May;389(5):467-75. [Content Brief] [3]. Xu P, et al. Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats. J Zhejiang Univ Sci B. 2014 Jan;15(1):84-91. [Content Brief]

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