D-Kynurenine|13441-51-5|-陌孚医药/Medlife

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D-Kynurenine

目录号: PC65958 纯度: ≥99%

CAS No. :13441-51-5

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中文名称	D-Kynurenine
中文别名	D-犬尿氨酸;D-2-氨基-4-(2-氨基苯基)-4-氧代丁酸;犬尿氨酸;D-犬尿氨酸硫酸盐;D-2-氨基-4-[2-氨基苯基]-4-氧丁酸
英文名称	D-Kynurenine
英文别名	(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;D-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;(2R)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;D-Kynurenine;D-KYNURENINE, FREE BASE;A-Anthraniloyl-D-alanine;β-Anthraniloyl-D-alanine;D-Kynurenine sulfate;REF DUPL: D-Kynurenine;beta-Anthraniloyl-D-alanine;(R)-α,2-Diamino-γ-oxobenzenebutanoic acid;D-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID;R-2-Amino-4-[2-aminophenyl]-4-oxobutanoic acid;D-kynurenine free base;DK8PQD0WC5;Kynurenine, D-;GTPL5799;Benzenebutanoic acid, alpha,2-diamino-gamma-oxo-, (R)-;Benzenebutanoic acid, alpha,2-diamino-gamma-oxo
Cas No.	13441-51-5
分子式	C₁₀H₁₂N₂O₃
分子量	208.21
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

D-kynurenine (10, 40, 60, and 100 μM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 μM). 10 μM D-kynurenine markedly attenuates E-cadherin level. 10 μM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 μM D-kynurenine-induced up-regulation of CYP1A1, 10 μM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 μM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Ketones, Aldehydes, Acids