β-Nicotinamide mononucleotide|1094-61-7|(烟酰胺单核苷酸; β-NM; NMN)-陌孚医药/Medlife

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β-Nicotinamide mononucleotide (Synonyms: 烟酰胺单核苷酸; β-NM; NMN)

目录号: PC65651 纯度: ≥99%

CAS No. :1094-61-7

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中文名称	β-Nicotinamide mononucleotide
中文别名	Β-烟酰胺单核苷酸;烟酰胺核苷酸（Beta-NMN）;[(2R,3S,4R,5R)-5-(3-氨基甲酰吡啶-1-鎓-1-基)-3,4-二羟基四氢呋喃-2-基]甲基磷酸氢酯;beta-烟酰胺单核苷酸;NMN（β-烟酰胺单核苷酸） I 级;NMN(β-烟酰胺单核苷酸)I级;β-烟酰胺单核苷酸[合成];曲司氯铵;烟酰胺单核苷酸;烟酰胺核苷酸;烟酰胺核苷酸（β-NMN）;医药中间体;β-烟酰胺核糖单磷酸盐;A-烟酰胺单核苷酸;Β-烟酰胺单核苷酸(Β-NMN);Β-烟酰胺单核苷酸(烟酰胺核苷酸);NMN(Β-烟酰胺单核苷酸;β-烟酰胺单核苷酸(NMN);β-烟酰胺单核苷酸-烟酰胺单核苷酸;烟酰胺核苷酸 NMN;烟酰胺核苷酸 (NMN)
英文名称	β-Nicotinamide mononucleotide
英文别名	Pyridinium,3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-, inner salt;beta-Nicotinamide Mononucleotide;NMN;β-nicotinamide D-ribonucleotide;β-Nicotinamide Monon;β-Nicotinamide Mononucleotide;β-NM;β-NMN;Nicotinamide ribotide;3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium;3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium;Nicotinamide mononucleotide;Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt;β-Nicotinamide ribose monophosphate;Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate;Nicotinamide ribonucleoside 5'-phosphate;Nicotinamide ribonucleotide;beta-D-NMN;beta-NMN;β-D-NMN;NMN zwitterion;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide;1-[5-O-(Hydroxyphosphinato)pentofuranosyl]pyridin-1-ium-3-carboximidate;1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[[hydroxy(oxido)phosphoryl]oxymethyl]oxolan-2-yl]pyridin-1-ium-3-ca;CID 138396994;β-NicotinamideMononucleotide;β-Nicotinamide Mononucleotide ，NMN;beta-nicotinamide D-ribonucleotide;nicotinamide D-ribonucleotide;beta-Nicotinamide ribonucleotide;2KG6QX4W0V;((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-d;β-Nicotinamide Mononucleotide(NMN)
Cas No.	1094-61-7
分子式	C₁₁H₁₅N₂O₈P
分子量	334.22
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimers disease, and complications associated with obesity.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

β-nicotinamide mononucleotide has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimers disease, and complications associated with obesity.
The intracellular NAD levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD levels are dramatically increased by supplement of NAD precursors NAM or NMN (0.5-1 mM). NAD precursor NMN treatment inhibited CD8 T cells activation and function.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

β-Nicotinamide mononucleotide(500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction.
Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite β-Nicotinamide mononucleotide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD level of respective Nampt KO and β-Nicotinamide mononucleotide-treated tumors are confirmed.
β-nicotinamide mononucleotide ameliorates glucose intolerance by restoring NAD levels in HFD-induced T2D mice. β-nicotinamide mononucleotide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

结构分类

Ketones, Aldehydes, Acids