5-Aminolevulinic acid hydrochloride|5451-09-2|(5-氨基乙酰丙酸盐酸盐; 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride)-陌孚医药/Medlife

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5-Aminolevulinic acid hydrochloride (Synonyms: 5-氨基乙酰丙酸盐酸盐; 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride)

目录号: PC65626 纯度: ≥98.0%

CAS No. :5451-09-2

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中文名称	5-Aminolevulinic acid hydrochloride
中文别名	5-氨基乙酰丙酸盐酸盐;5-Aminolevulinic Acid Hydrochloride 5-氨基乙酰丙酸盐酸盐;5-氨基酮戊酸;5-氨基酮戊酸盐酸盐;盐酸氨酮戊酸;5-氨基-4-氧戊酸盐酸盐;5-氨基乙酰丙;5-氨基左旋糖酸盐;Β-氨基乙酰丙酸盐酸盐;氨基酮戊酸;盐酸-5-氨基果糖酸;盐酸-5-氨基左旋糖酸;5-氨基-4-酮戊酸盐酸盐;5-氨基左旋糖酸盐酸盐;DELTA-氨基乙酰丙酸盐酸盐
英文名称	5-Aminolevulinic acid hydrochloride
英文别名	5-Amino-4-oxopentanoic acid hydrochloride;5-amino-3-oxopentanoic acid;d-Aminolevulinic Acid, HCl;5-Aminolevulinic-3-13C Acid HCl;5-Amino-15N-levulinic Acid HCl;5-Amino-4-ketovaleric acid hydrochloride;5-Aminolevulinic acid (hydrochloride);5-Aminolevulinic acid hydrochloride;5-Aminolevulinic Acid Hydrochloride Salt;AMINOLEVULINIC ACID HCL, 5-(RG);5-ALA;ALA;δ-Aminolevulinic acid hydrochloride;5-Aminolaevulinic acid hydrochloride;Aminolevulinic acid hydrochloride;Levulan;Levulan Kerastick;5-Aminolevulinic acid HCl;delta-Aminolevulinic acid hydrochloride;Gliolan;Aminolevulinic Acid HCl;Ameluz;5-Aminolevulinate hydrochloride;5-amino-levulinic acid hydrochloride;Pentanoic acid, 5-amino-4-oxo-, hydrochloride;V35KBM8JGR;5-Aminolevulinic Acid Hydrochioride
Cas No.	5451-09-2
分子式	C₅H₁₀ClNO₃
分子量	167.59
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

5-Aminolevulinic acid hydrochloride (ALA) is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neu

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Ketones, Aldehydes, Acids

溶解度数据	体外研究: DMSO : 100 mg/mL(596.69 mM;Need ultrasonic) H₂O : 16.67 mg/mL(99.47 mM;ultrasonic and warming and heat to 60°C) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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