Folinic acid calcium.|1492-18-8|(亚叶酸钙; Leucovorin calcium; Calcium folinate)-陌孚医药/Medlife

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Folinic acid calcium. (Synonyms: 亚叶酸钙; Leucovorin calcium; Calcium folinate)

目录号: PC65678 纯度: ≥99%

CAS No. :1492-18-8

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中文名称	Folinic acid calcium.
中文别名	亚叶酸钙;甲叶钙;甲酰四氢叶酸钙;N-(4-(((2-氨基-5-甲酰-5,6,7,8-四氢-4-羟基-6-蝶啶)甲基)氨基)苯甲酰)-L-谷氨酸钙盐;亚乙酸;5-甲基-5,6,7,8-四氢蝶酰-L-单谷氨酸钙盐;亚叶酸钙水合物;Calcium Folinate Hydrate 亚叶酸钙水合物;亚硒酸钠;亚叶酸钙 EP标准品;亚叶酸钙 USP标准品;亚叶酸钙标准品;亚叶酸钙(FOLINIC ACID)(AS);亚叶酸钙标准品(JP);亚叶酸钙盐水合物;叶酸;叶酸钙(钙Levofolinate);叶酸相关物质A USP标准品;叶酸杂质A;N-[4-[(2-氨基-5-甲酰基-1,4,5,6,7,8,-六氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基-L-谷氨酸钙盐五水合物;N-[4-[(2-氨基-5-甲酰基-4-氧代-1,6,7,8-四氢-6-蝶啶基)甲基]氨基]苯甲酰基-L-谷氨酸;N-[4-[[(2-氨基-5-甲酰-5,6,7,8-四氢-4-羟基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸钙盐;N5-甲酰-5,6,7,8-四氢叶酸钙;甲酰基-5,6,7,8-四氢叶酸钙盐;维生素B11(叶酸);叶素钙;叶醛酸钙;维生素B11;噬橙菌因子钙;亚叶酸钙 1G
英文名称	Folinic acid calcium
英文别名	Calcium folinatc;Folinic acid Calcium salt;calcium folinate;Folinic acid calcium salt USP28;Calcium leucovorin;LeucovorinCalcium;CALCIUM FOLINATE(FOLINIC ACID)(RG);Folinic acid;Calcium Levofolinate;calcium2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl] aminopentanedioate;L-Calcium Folinate;Calcium Folinate Hydrate;Folinic acid calcium salt hydrate;5-FORMLYL-5,6,7,8-TETRAHYDROFOLIC ACID,CALCIUM SALT;CALCIUM FOLINATE, CELL CULTURE TESTED;5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt;5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt;5-HCO-H4PteGlu;Citrovorum factor calcium salt;Leucovorin calcium salt;N-(4-(((2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt;CF-CA;Ca folinate;lederfoline;Leucovorine;Leuovorin calcium;CITROVORUM FACTOR;Calcium L-folinate;Calcium Leucoverin;API0026022;Folinic acid calcium
Cas No.	1492-18-8
分子式	C₂₀H₂₁CaN₇O₇
分子量	511.50
包装储存	4°C, Sealed and stored away from moisture and light；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

生物活性	Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Sealed and stored away from moisture and light；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

溶解度数据	体外研究: H₂O : 50 mg/mL(97.75 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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