L-Kynurenine.|2922-83-0|(L-犬尿氨酸 (标准品))-陌孚医药/Medlife

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L-Kynurenine. (Synonyms: L-犬尿氨酸 (标准品))

目录号: PC65620 纯度: ≥99%

CAS No. :2922-83-0

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中文名称	L-Kynurenine.
中文别名	L-犬尿氨酸水合物;L-Kynurenine Hydrate L-犬尿氨酸水合物;L-犬尿氨酸;L-犬尿氨酸标准品;犬尿氨酸;L-犬尿氨酸,13C4,15N
英文名称	L-Kynurenine
英文别名	(S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;L-Kynurenine;L-Kynurenine Hydrate;Benzenebutanoic acid, a,2-diamino-g-oxo-, (aS)-;Kynurenine;β-Anthraniloyl-L-alanine;L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;Kynurenin;L-3-(o-Aminobenzoyl)alanine;Kynurenine, L-;3-Anthraniloyl-L-alanine;(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;YGPSJZOEDVAXAB-QMMMGPOBSA-N;02JW4J5R44;Quinurenine;Benzenebutanoic acid, alpha,2-diamino-gamma-oxo-, (alphaS)-;(S)-alpha,2-Diamino-gamma-oxobenzenebutanoic acid;L-2-Amino-3-(2-aminobenzoyl)propionic acid;L-KynurenineHydrate;KYN;DL-Kynureninefree base;3-anthraniloyl-alani
Cas No.	2922-83-0
分子式	C₁₀H₁₂N₂O₃
分子量	208.21
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. In rats, this tryptophan metabolite causes hypotension, which is partly counteracted by Kv7 channel inhibition. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

溶解度数据	体外研究: H₂O : 20 mg/mL(96.06 mM;Need ultrasonic) DMSO : 12.5 mg/mL(60.04 mM;ultrasonic and warming and heat to 60°C) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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