Adenosine 5'-monophosphate monohydrate.|18422-05-4|(5'-AMP monohydrate)-陌孚医药/Medlife

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Adenosine 5'-monophosphate monohydrate. (Synonyms: 5'-AMP monohydrate)

目录号: PC65821 纯度: ≥99%

CAS No. :18422-05-4

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中文名称	Adenosine 5'-monophosphate monohydrate.
中文别名	腺苷-5'-单磷酸一水合物;腺苷-5-磷酸;腺苷-5'-磷酸;腺苷-5'-磷酸(一水);3,4-二甲氧基苯丙胺;5’-腺苷单磷酸一水合物;腺苷-5"-单磷酸一水合物;腺苷-5’-单磷酸一水合物;腺苷-5’-磷酸;腺苷-5'-单磷酸一水合物AMP(酵母来源);腺苷-5''-单磷酸一水合物;腺苷-5-单磷酸一水合物;腺苷-5''-磷酸;5’-磷酸腺苷;5'-一磷酸腺苷,不含酸,来源于酵母;腺苷-5'-单磷酸水合物;5′-腺苷酸;肌肉腺苷酸;5'-磷酸腺苷,AMP;腺苷-5`-单磷酸水合物;腺苷-5'-磷酸一水合物;腺苷-5'-单磷酸一水;腺苷-5'-磷酸(+4℃);腺苷-5'-磷酸一水物;布拉地新杂质5
英文名称	Adenosine 5'-monophosphate monohydrate
英文别名	Adenosine 5'-monophosphate monohydrate;5'-AMP H2O;5'-AMP MONOHYDRATE;ADENOSINE 5'-MONOPHOSPHORIC ACID MONOHYDRATE;ADENYLIC ACID MONOHYDRATE;A-5'-P;Adenosine-5'-monophosphate;5'-AMP;5'-AMPH2;Adenosine 5′-monophosphate monohydrate;AMP monohydrate;AMP.H2O;5′-AMP;A-5′-P;AMP;Adenosine-5’-phospho;AMP monohydrate;5'-AMP=Adenylicacid;adenosine 5'-monophosphate;5'-adenylic acid;Adenosine monophosphate;adenosine phosphate;adenylic acid;adenosine 5'-phosphate;Phosphaden;adenylate;Phosphentaside;Adenovite;Phosaden;Cardiomone;Lycedan;Vitamin B8;My-B-Den;Myoston;Ergadenylic acid;Monophosphadenine;Muscle adenylic acid;Muskeladenylsaeure;5'-adenosine monophosphate;AMP (nucleotide);Adenosine 5'-(dihydrogen phosphate);Adenosine 5'-phosphoric acid;Adenosini phosphas;Adenosine-5-monophosphor
Cas No.	18422-05-4
分子式	C₁₀H₁₄N₅O₇P
分子量	347.22
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Adenosine 5-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite
HSV-1

体外研究(In Vitro)

Adenosine 5-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400?μM in RAW264.7 cells. Adenosine 5-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α)and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400?μM, Adenosine 5-monophosphate monohydrate exhibits the maximum inhibition.Exposure of cells to Adenosine 5-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

C57BL/6J mice treated with Adenosine 5-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8?h) and 33.3% (24?h), whereas survival rate in Adenosine 5-monophosphate monohydrate-treated mice (n=15) is 100% (8?h) and 93.3% (24?h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5-monophosphate monohydrate group.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

溶解度数据	体外研究: H₂O : 5 mg/mL(13.69 mM;Need ultrasonic and warming) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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