Adenosine5'-(tetrahydrogen triphosphate), disodium salt, hydrate (8CI,9CI);Adenosine 5’-triphosphate disodium salt hydrate;Adenosine 5'-Triphosphate Disodium Salt Hydrate;ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL&;5′-ATP-Na2;5'-ATP 2Na Hydrate;5'-ATP-Na2;Adenosine 5‘-triphosphate,disodium salt hydrate;Adenosine 5'-triphosphate;Adenosine 5-triphosphate,disodium salt hydrate;ADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT HYDR.,CALCIUM FREE;Adenosine-5'-triphosphate disodium salt hydrate,water;adenosine-5'-triphosphate disodium trihydrate;ATP disodium hydrate;ADENOSINE 5’-TRIPHOSPHATE DISODIUM SAL&;5’-ATP-Na2;ADENOSINE-5’-TRIPHOSPHATE DISODIUM SALT HYDR., CALCIUM FREE;ADENOSINE-5-TRIPHOSPHATE DISODIUM SALT (ATP-Na2) extrapure for biochemistry;5μ-ATP-Na2, ATP hydrate disodium salt;Adenosine-5’-triphosphate disodium salt hydrate, 99+%;5'-ATP,Na2;adenosine-5'-triphosphate disodium salt hydrate;CID 131664345
Cas No.
34369-07-8
分子式
C10H16N5Na2O14P3
分子量
569.16
包装储存
4°C, sealed storage and away from moisture;*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture);
生物活性
ATP disodium salt hydrate (Adenosine 5-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation.
性状
Solid
IC50 & Target[1][2]
Human Endogenous Metabolite
体外研究(In Vitro)
ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.Animal Model:
运输条件
Room temperature or refrigerated transport.
储存方式
4°C, sealed storage and away from moisture;*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture);