Cyclic ADP-ribose ammonium||-陌孚医药/Medlife

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Cyclic ADP-ribose ammonium

目录号: PC62092 纯度: ≥99.0%

商品编号	规格	价格	会员价	是否有货	数量
PC62092-1mg	1mg	询价	询价

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中文名称	Cyclic ADP-ribose ammonium
英文名称	Cyclic ADP-ribose ammonium
包装储存	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
性状	Solid
IC50 & Target[1][2]	Calcium mobilization TRPM2 channels Endogenous metabolite
体外研究(In Vitro)	cADPR (20 nM) elicits a large rapid Ca release in sea urchin eggs homogenates. cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes. cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
结构分类	Others

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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