Lipopolysaccharides||-陌孚医药/Medlife

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Lipopolysaccharides

目录号: PC63809 纯度: 98%

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中文名称	Lipopolysaccharides
英文名称	Lipopolysaccharides
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome.
性状	Solid
IC50 & Target[1][2]	TLR4

体外研究(In Vitro)

Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Saccharides

来源

surface of Gram-negative bacteria

溶解度数据	体外研究: H₂O : 5 mg/mL (Need ultrasonic) 体内研究: 请根据您的

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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