cGAMP diammonium||-陌孚医药/Medlife

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cGAMP diammonium

目录号: PC61943 纯度: ≥95%

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中文名称	cGAMP diammonium
英文名称	cGAMP diammonium
包装储存	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP diammonium directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

cGAMP (5 μg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by spleen cells of immunized mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:

运输条件

Room temperature or refrigerated transport.

储存方式

-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Others

溶解度数据	体外研究: H₂O : 100 mg/mL(141.15 mM;Need ultrasonic) 配制储存液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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