Sophoridine|6882-68-4|(槐定碱)-陌孚医药/Medlife

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Sophoridine (Synonyms: 槐定碱)

目录号: PC63081 纯度: ≥99%

CAS No. :6882-68-4

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中文名称	Sophoridine
中文别名	槐定碱;苦参次碱-15-酮;(7aR,13aS,13bS,13cR)-十二氢-1H,5H,10H-二吡啶并[2,1-f:3',2',1'-ij][1,6]萘啶-10-酮;(5β)-苦参次碱-15-酮
英文名称	Sophoridine
英文别名	sophoridine;allomatrine;(-)Sophoridine;SOPHORIDINE(RG) PrintBack;5-Epidihydrosophocarpine;Bio-0637;Dihydro-5-episophocarpine;matridin-15-one;(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one;(5β)-Matridin-15-one;[ "" ];Sophoridin;l-Sophoridine;W5S1M800J7;C15H24N2O;(+)-Matrine;6-Allomatrine;Sophoridine,(S);6.beta.-Matrine;Tetrahydroisosophoramine;MLS006011816;ZSBXGIUJOOQZMP-BHPKHCPMSA-N
Cas No.	6882-68-4
分子式	C₁₅H₂₄N₂O
分子量	248.36
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity.
性状	Solid
体外研究(In Vitro)	Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM. Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively. Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:BALB/c homozygo
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Alkaloids Pyridin
来源	Plants

溶解度数据	体外研究: DMSO : 50 mg/mL(201.32 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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